| 506 |
September 24, 1927 |
Carnegie Mellon at Westminster (Pennsylvania) |
25–0 |
Defended · #1 |
| 507 |
October 1, 1927 |
Thiel at Carnegie Mellon |
0–40 |
Defended · #2 |
| 508 |
October 8, 1927 |
Drexel at Carnegie Mellon |
0–58 |
Defended · #3 |
| 509 |
October 15, 1927 |
Washington & Jefferson at Carnegie Mellon |
20–6 |
New champion: Washington & Jefferson |
| 510 |
October 22, 1927 |
Washington & Jefferson at Lafayette |
14–0 |
Defended · #1 |
| 511 |
October 29, 1927 |
Washington & Jefferson at Thiel |
33–0 |
Defended · #2 |
| 512 |
November 5, 1927 |
Pittsburgh at Washington & Jefferson |
0–0 |
Defended (tie) · #3 |
| 513 |
November 12, 1927 |
Washington & Jefferson at Bucknell |
19–3 |
Defended · #4 |
| 514 |
November 24, 1927 |
West Virginia at Washington & Jefferson |
6–6 |
Defended (tie) · #5 |